Old age population in developing countries is rising as also chronic diseases like Alzheimer’s disease (AD) with increase in morbidity and disability. Depression is considered increasingly both as a risk factor and prodromal feature in AD. Depression and Diabetes mellitus are now both considered as risk factors in conversion of Mild Cognitive Impairment (MCI) to AD with neuro-inflammation as a possible underlying cause. Cognitive deficits occurring in old age should be evaluated thoroughly and followed up at regular intervals.
Key words: Alzheimer’s disease, depression, MCI, Risk, Prodrome.